We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Ions doped melanin nanoparticle as a multiple imaging agent.
- Authors
Shin-Woo Ha; Hee-Sang Cho; Young Il Yoon; Moon-Sun Jang; Kwan Soo Hong; Hui, Emmanuel; Jung Hee Lee; Tae-Jong Yoon
- Abstract
Background: Multimodal nanomaterials are useful for providing enhanced diagnostic information simultaneously for a variety of in vivo imaging methods. According to our research findings, these multimodal nanomaterials offer promising applications for cancer therapy. Results: Melanin nanoparticles can be used as a platform imaging material and they can be simply produced by complexation with various imaging active ions. They are capable of specifically targeting epidermal growth factor receptor (EGFR)-expressing cancer cells by being anchored with a specific antibody. Ion-doped melanin nanoparticles were found to have high bioavailability with long-term stability in solution, without any cytotoxicity in both in vitro and in vivo systems. Conclusion: By combining different imaging modalities with melanin particles, we can use the complexes to obtain faster diagnoses by computed tomography deep-body imaging and greater detailed pathological diagnostic information by magnetic resonance imaging. The ion-doped melanin nanoparticles also have applications for radio-diagnostic treatment and radio imaging-guided surgery, warranting further proof of concept experimental.
- Subjects
MELANINS; NANOPARTICLES; IONS; EPIDERMAL growth factor receptors; COMPUTED tomography; MAGNETIC resonance imaging; BIOAVAILABILITY
- Publication
Journal of Nanobiotechnology, 2017, Vol 15, p1
- ISSN
1477-3155
- Publication type
Article
- DOI
10.1186/s12951-017-0304-3