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- Title
Apparent diffusion coefficient measurements with diffusion-weighted imaging for differential diagnosis of soft-tissue tumor.
- Authors
Yu Zou; Qi-Dong Wang; Min Zong; Yue-Fen Zou; Hai-Bin Shi; Zou, Yu; Wang, Qi-Dong; Zong, Min; Zou, Yue-Fen; Shi, Hai-Bin
- Abstract
<bold>Objectives: </bold>To evaluate the diagnostic potential of apparent diffusion coefficient (ADC) values of diffusion-weighted imaging (DWI) in distinguishing malignant and benign soft-tissue tumors.<bold>Materials and Methods: </bold>Published studies were retrieved through comprehensive search in various computerized databases. High-quality studies relevant to ADC values of DWI in differential diagnosis of soft-tissue tumors were screened using our stringent inclusion and exclusion criteria for this meta-analysis. The standard mean difference with 95% confidence interval (95% CI) was estimated. Statistical analyses were performed using the STATA statistical software (Stata Co., College Station, TX, USA).<bold>Results: </bold>Thirteen cohort studies were finally included, and these studies provided the required information on the diagnostic value of diffusion magnetic resonance imaging in soft-tissue tumors. The 13 studies contained a combined total of 344 malignant soft tumors and 315 benign soft tumors. The results of our meta-analysis revealed that mean ADC value in patients with malignant soft-tissue tumor decreased significantly in comparison with the ADC values obtained in patients with benign soft-tissue tumor (P < 0.001). Country-stratified analysis suggested that ADC value might play a predictive role in the differential diagnosis of soft-tissue tumors in China (P = 0.007), Egypt (P < 0.001), Germany (P = 0.001), Japan (P = 0.049), and The Netherlands (P < 0.001).<bold>Conclusion: </bold>Our results provide strong evidence that patients diagnosed with malignant soft-tissue tumors have low ADC values of DWI compared to those with benign soft-tissue tumors. Therefore, ADC measurements with DWI may be reliable in differential diagnosis of soft-tissue tumors.
- Subjects
SOFT tissue tumors; DIFFUSION coefficients; DIFFUSION magnetic resonance imaging; DIFFERENTIAL diagnosis; CONFIDENCE intervals
- Publication
Journal of Cancer Research & Therapeutics, 2016, Vol 12, Issue 2, p864
- ISSN
0973-1482
- Publication type
journal article
- DOI
10.4103/0973-1482.164700