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- Title
Mid-life adiposity factors relate to blood–brain barrier integrity in late life.
- Authors
Gustafson, D. R.; Karlsson, C.; Skoog, I.; Rosengren, L.; Lissner, L.; Blennow, K.
- Abstract
Objective. We explored the relationship between adiposity factors measured during mid-life and blood–brain barrier (BBB) integrity measured via the cerebrospinal fluid/serum (CSF/S) albumin ratio in late life. Adiposity factors included body mass index and blood levels of sex hormone binding globulin (SHBG) and leptin. Design. Retrospective analyses over 24 years within a longitudinal study. Setting. Population-based sample. Subjects. Eighty-one women. Main outcome measures. CSF/S albumin ratio. Results. The CSF/S albumin ratio measured at age 70–84 years was higher amongst women who were overweight or obese (6.50 ± 2.79 vs. 5.23 ± 1.61, age-adjusted P = 0.012), and was inversely correlated with SHBG (age-adjusted r = −0.321, P < 0.005) at age 46–60 years. In stepwise regression models, SHBG predicted the CSF/S albumin ratio (beta = −0.017, R2 = 0.107, P = 0.007). The best model ( R2 = 0.187) predicting CSF/S albumin ratio included SHBG, age group (age 46 years versus >46), overweight or obesity, and an age group by SHBG interaction. Conclusions. Lower levels of SHBG in mid-life were related to worse BBB integrity in women after 24 years in late life, even considering other adiposity factors. SHBG may be important for understanding sex hormone-mediated mechanisms in brain health or as an independent marker of adipose tissue, the largest endocrine organ.
- Subjects
OBESITY; AGING; BODY mass index; SEX hormones; GLOBULINS; HEALTH outcome assessment
- Publication
Journal of Internal Medicine, 2007, Vol 262, Issue 6, p643
- ISSN
0954-6820
- Publication type
Article
- DOI
10.1111/j.1365-2796.2007.01869.x