We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Effects of Metal Ions on Plasma Membrane Mg<sup>2+</sup>-ATPase in Rat Uterus and Ovaries.
- Authors
MILOŠEVIĆ, MAJA; PETROVIĆ, SNJEŽANA; DEMAJO, MIROSLAV; HORVAT, ANICA
- Abstract
The in vitro effects of cadmium and mercury were investigated on the Mg2+-ATPase activity of plasma membranes from the rat ovary and uterus. ATP hydrolyzing activities were significant and dose-dependent-inhibited in both plasma membrane preparations by both metals. According to the IC50 and apparent Ki, Cd2+ was most potent in the ovary, while Hg2+ was most potent in the uterus. In ovaries and uterus, Cd2+ inhibits competitively, while Hg2+ inhibits noncompetitively in both organs. The observed inhibition was a consequence of direct action of the chosen metal ions on the enzyme protein and by decreasing ATP hydrolysis, Hg2+ and Cd2+ may affect mammalian fertility.
- Subjects
METAL ions; LABORATORY rats; CELL membranes; OVARIES; UTERUS
- Publication
Annals of the New York Academy of Sciences, 2005, Vol 1048, Issue 1, p445
- ISSN
0077-8923
- Publication type
Article
- DOI
10.1196/annals.1342.061