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- Title
Structure and Biosynthetic Assembly of Gulmirecins, Macrolide Antibiotics from the Predatory Bacterium Pyxidicoccus fallax.
- Authors
Schieferdecker, Sebastian; König, Stefanie; Weigel, Christiane; Dahse, Hans ‐ Martin; Werz, Oliver; Nett, Markus
- Abstract
The gulmirecins constitute a new class of glycosylated macrolides that were isolated from the predatory bacterium Pyxidicoccus fallax HKI 727. Their structures were solved by a combination of NMR spectroscopic experiments and chemical derivatization. Analysis of the annotated gulmirecin gene cluster complemented the configurational assignment and provided insights into the stereochemical course of the biosynthetic assembly. The gulmirecins exhibit strong activity against staphylococci, including methicillin-resistant Staphylococcus aureus, but no cytotoxic effects on human cells.
- Subjects
PHYTONCIDES; ANTIBIOTICS; MICROBIAL metabolites; MACROCYCLIC compounds; BIOSYNTHESIS
- Publication
Chemistry - A European Journal, 2014, Vol 20, Issue 48, p15933
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.201404291