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- Title
Sensitive and Convenient Detection of microRNAs Based on Cascade Amplification by Catalytic DNAzymes.
- Authors
Tian, Tian; Xiao, Heng; Zhang, Zhengan; Long, Yuelin; Peng, Shuang; Wang, Shaoru; Zhou, Xiang; Liu, Songmei; Zhou, Xin
- Abstract
On target: We have developed two cascade amplification strategies that combine duplex specific nuclease (DSN) amplicon with either G‐quadruplex‐based DNA peroxidase or 8–17 DNAzyme amplicon for miRNA detection. In this way, sensitive and convenient detection of miRNAs was achieved. In the DNA peroxidase‐based system, a visual color change could be observed in the presence of target miRNAs (see scheme).
- Publication
Chemistry - A European Journal, 2013, Vol 19, Issue 1, p92
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.201203344