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- Title
Development and validation of a nomogram for predicting the risk of vasovagal reactions after plasma donation.
- Authors
Zhao, Peizhe; Dong, Demei; Dong, Rong; Zhou, Yuan; Hong, Yan; Xiao, Guanglin; Li, Zhiye; Su, Xuelin; Zheng, Xingyou; Liu, Xia; Zhang, Demei; Li, Ling; Liu, Zhong
- Abstract
Background and Objectives: Vasovagal reactions (VVRs) are the most common adverse reactions and are frequently associated with serious donor adverse events. Even mild VVRs can lead to a significant reduction in the likelihood of subsequent donations. The purpose of this study is to explore the factors related to the occurrence of VVRs after plasma donation and to construct a nomogram to identify individuals at risk for VVRs to improve the safety of plasma donors. Materials and Methods: We collected the donation data from July 2019 to June 2020 from a plasma center in Sichuan, China, to explore the independent risk factors for vasovagal reactions. From these data, we constructed and validated a predictive model for vasovagal reactions. Results: VVRs after plasma donation occurred 737 times in 120 448 plasma donations (0.66%). Gender, season, donor status, weight, pulse, duration of donation, and cycle were independent risk factors for VVRs (P< 0.05). The concordance index (C‐index) of a logistic model in the derivation cohort was 0.916, with a Hosmer‐Lemeshow goodness‐of‐fit probability of 0.795. The C‐index of a logistic model in the validation cohort was 0.916, with a Hosmer‐Lemeshow goodness‐of‐fit probability of 0.224. The calibration curve showed that the predicted results were in good agreement with the actual observed results. Conclusion: This study preliminarily constructed and verified a prediction model for VVRs after plasma donation. The model nomogram is practical and can identify high‐risk donors.
- Subjects
SICHUAN Sheng (China); NOMOGRAPHY (Mathematics); PREDICTION models; MODEL validation; FORECASTING
- Publication
Journal of Clinical Apheresis, 2023, Vol 38, Issue 5, p622
- ISSN
0733-2459
- Publication type
Article
- DOI
10.1002/jca.22074