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- Title
A Study of the Therapeutic Spectrum of a Fixed-dose of Zotepine and its Relationship with Serum Concentrations of the Drug.
- Authors
Kondo, Tsuyoshi; Otani, Koichi; Ishida, Masayuki; Mihara, Kazuo; Tanaka, Osamu; Kaneko, Sunao; Fukushima, Yutaka
- Abstract
The therapeutic spectrum of zotepine, an antipsychotic drug and its relationship with serum concentration of the drug were investigated by a fixed-dose study (100mg/day in the first week, nd 200mg/day for the next 3 weeks) in 20 schizophrenic in patients. The mean percentages of symptom reduction in total Brief Psychiatric Rating Scale (BPRS) and three subgroups were 63-4 per cent for positive symptoms, 41-8 per cent for negative symptoms and 74-2 per cent for anxiety-depression respectively. Total, positive and negative symptoms were significantly reduced after 2 weeks (p<0-01), while a significant reduction in anxiety-depression symptoms was already found after 1 week (p<0-01). There were significant differences in the values of percentage improvement in total and positive symptoms after 2 weeks (p<0-05 and negative symptoms after 1 week (p<0-05) between responders (more than 50 per cent reduction in total BPRS scores at the end of the study) and nonresponders. In 18 patients (90 per cent), the clinical response at 2 weeks corresponded well to the final outcome. No definite relationship was found between serum zotepine concentration ad the clinical efficacy.
- Subjects
ANTIPSYCHOTIC agents; SERUM; PEOPLE with schizophrenia; ANXIETY; MENTAL depression; PSYCHOPHARMACOLOGY
- Publication
Human Psychopharmacology: Clinical & Experimental, 1993, Vol 8, Issue 2, p133
- ISSN
0885-6222
- Publication type
Article
- DOI
10.1002/hup.470080207