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- Title
Platelet and monocyte activity markers and mediators of inflammation in Takotsubo cardiomyopathy.
- Authors
Pirzer, Rainer; Elmas, Elif; Haghi, Dariusch; Lippert, Christiane; Kralev, Stefan; Lang, Siegfried; Borggrefe, Martin; Kälsch, Thorsten
- Abstract
Patients with Takotsubo cardiomyopathy (TC) often present with symptoms similar to those of myocardial infarction (MI). We analyzed blood concentrations of mediators of inflammation and platelet- and monocyte-activity markers in patients with TC and MI for significant differences. Clinical data of patients with TC ( n = 16) and acute MI ( n = 16) were obtained. Serial blood samples were taken at the time of hospital admission ( t), after 2-4 days ( t) and after 4-7 weeks ( t), respectively. Plasma concentrations of interleukin (IL)-6, IL-7, soluble CD40 ligand (sCD40L), and monocyte chemotactic protein 1 (MCP-1) were determined with an ELISA. Tissue factor binding on monocytes , platelet-activation marker CD62P, platelet CD40-ligand (CD40L), and platelet-monocyte aggregates were measured using flow cytometry. Expression of CD62P on platelets and IL-6 plasma levels were significantly lower in patients with TC compared to MI at the time of hospital admission. IL-7 plasma levels were significantly elevated in patients with TC compared to patients with MI at 2-4 days after hospital admission. No significant differences were observed concerning sCD40L and MCP-1 plasma levels, tissue factor binding on monocytes, CD40L expression on platelets, and platelet-monocyte aggregates at any point in time. Our results indicate that inflammatory mediators and platelet-activity markers contribute to the differences in the pathogenesis of MI and TC.
- Subjects
CARDIOMYOPATHIES; MONOCYTES; BLOOD platelets; BIOMARKERS; BLOOD plasma; INFLAMMATORY mediators; FLOW cytometry; GENE expression
- Publication
Heart & Vessels, 2012, Vol 27, Issue 2, p186
- ISSN
0910-8327
- Publication type
Article
- DOI
10.1007/s00380-011-0132-6