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- Title
Total Synthesis of Decahydroquinoline Poison Frog Alkaloids ent- cis -195A and cis -211A.
- Authors
Okada, Takuya; Wu, Naizhen; Takashima, Katsuki; Ishimura, Jungoh; Morita, Hiroyuki; Ito, Takuya; Kodama, Takeshi; Yamasaki, Yuhei; Akanuma, Shin-ichi; Kubo, Yoshiyuki; Hosoya, Ken-ichi; Tsuneki, Hiroshi; Wada, Tsutomu; Sasaoka, Toshiyasu; Shimizu, Takahiro; Sakai, Hideki; Dwoskin, Linda P.; Hussaini, Syed R.; Saporito, Ralph A.; Toyooka, Naoki
- Abstract
The total synthesis of two decahydroquinoline poison frog alkaloids ent-cis-195A and cis-211A were achieved in 16 steps (38% overall yield) and 19 steps (31% overall yield), respectively, starting from known compound 1. Both alkaloids were synthesized from the common key intermediate 11 in a divergent fashion, and the absolute stereochemistry of natural cis-211A was determined to be 2R, 4aR, 5R, 6S, and 8aS. Interestingly, the absolute configuration of the parent decahydroquinoline nuclei of cis-211A was the mirror image of that of cis-195A, although both alkaloids were isolated from the same poison frog species, Oophaga (Dendrobates) pumilio, from Panama.
- Subjects
PANAMA; DENDROBATIDAE; MIRROR images; STEREOCHEMISTRY
- Publication
Molecules, 2021, Vol 26, Issue 24, p7529
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules26247529