We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
A Novel Gel-Forming Solution Based on PEG-DSPE/Solutol HS 15 Mixed Micelles and Gellan Gum for Ophthalmic Delivery of Curcumin.
- Authors
Sai, Na; Dong, Xiaoxv; Huang, Pingqing; You, Longtai; Yang, Chunjing; Liu, Yi; Wang, Wenping; Wu, Huimin; Yu, Yingchao; Du, Yuanyuan; Leng, Xin; Yin, Xingbin; Qu, Changhai; Ni, Jian
- Abstract
Curcumin (Cur) is a naturally hydrophobic polyphenol with potential pharmacological properties. However, the poor aqueous solubility and low bioavailability of curcumin limits its ocular administration. Thus, the aim of this study was to prepare a mixed micelle in situ gelling system of curcumin (Cur-MM-ISG) for ophthalmic drug delivery. The curcumin mixed micelles (Cur-MMs) were prepared via the solvent evaporation method, after which they were incorporated into gellan gum gels. Characterization tests showed that Cur-MMs were small in size and spherical in shape, with a low critical micelle concentration. Compared with free curcumin, Cur-MMs improved the solubility and stability of curcumin significantly. The ex vivo penetration study revealed that Cur-MMs could penetrate the rabbit cornea more efficiently than the free curcumin. After dispersing the micelles in the gellan gum solution at a ratio of 1:1 (v/v), a transparent Cur-MM-ISG with the characteristics of a pseudoplastic fluid was formed. No obvious irritations were observed in the rabbit eyes after ocular instillation of Cur-MM-ISG. Moreover, Cur-MM-ISG showed a longer retention time on the corneal surface when compared to Cur-MMs using the fluorescein sodium labeling method. These findings indicate that biocompatible Cur-MM-ISG has great potential in ophthalmic drug therapy.
- Subjects
CURCUMIN; GELLAN gum; CRITICAL micelle concentration; MICELLES; MICELLAR solutions; PSEUDOPLASTIC fluids; HYDROCOLLOIDS; RF values (Chromatography)
- Publication
Molecules, 2020, Vol 25, Issue 1, p81
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules25010081