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- Title
tert-Butylphenolic Derivatives from Paenibacillus odorifer—A Case of Bioconversion.
- Authors
Nguyen, Thi-Bach-Le; Rouaud, Isabelle; Ferron, Solenn; Tomasi, Sophie; Delalande, Olivier; Chaillot, Laura; Pedeux, Rémy
- Abstract
Two compounds (<bold>1</bold>) and (<bold>2</bold>) containing <italic>tert</italic>-butylphenol groups were, for the first time, produced during the culture of <italic>Paenibacillus odorifer</italic>, a bacterial strain associated with the crustose lichen, <italic>Rhizocarpon geographicum</italic>. Their entire structures were identified by one-dimensional (1D) and two-dimensional (2D) NMR and high-resolution electrospray ionisation mass spectrometry (HRESIMS) spectroscopic analyses. Among them, Compound <bold>1</bold> exhibited significant cytotoxicity against B16 murine melanoma and HaCaT human keratinocyte cell lines with micromolar half maximal inhibitory concentration (IC50) values. Furthermore, after supplementation studies, a putative biosynthesis pathway was proposed for Compound <bold>1</bold> throughout a bioconversion by this bacterial strain of butylated hydroxyanisole (BHA), an antioxidant polymer additive.
- Subjects
PHENOLS; PAENIBACILLUS; RHIZOCARPON; BIOCONVERSION; NUCLEAR magnetic resonance
- Publication
Molecules, 2018, Vol 23, Issue 8, p1951
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules23081951