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- Title
Pyrrole Alkaloids from the Edible Mushroom Phlebopus portentosus with Their Bioactive Activities.
- Authors
Sun, Zhaocui; Hu, Meigeng; Sun, Zhonghao; Zhu, Nailiang; Yang, Junshan; Ma, Guoxu; Xu, Xudong
- Abstract
Seven pyrrole alkaloids, three of which are novel (phlebopines A–C (<bold>1</bold>–<bold>3</bold>)), were isolated from the fruiting bodies of the edible mushroom <italic>Phlebopus portentosus</italic>. Their structures were determined on the basis of spectroscopic data. All the isolated compounds were tested for their neuroprotective properties and acetylcholine esterase (AChE) inhibition activities. Compound <bold>7</bold> displayed remarkable neuroprotective effects against hydrogen peroxide (H2O2)-induced neuronal-cell damage in human neuroblastoma SH-SY5Y cells.
- Subjects
PYRROLES; ALKALOIDS; MUSHROOMS; BIOACTIVE compounds; NEUROPROTECTIVE agents
- Publication
Molecules, 2018, Vol 23, Issue 5, p1198
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules23051198