We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
The Role of Kinase Modulators in Cellular Senescence for Use in Cancer Treatment.
- Authors
Chang Sup Lee; Juhwa Baek; Sun-Young Han
- Abstract
Recently, more than 30 small molecules and eight monoclonal antibodies that modulate kinase signaling have been approved for the treatment of several pathological conditions, including cancer, idiopathic pulmonary fibrosis, and rheumatoid arthritis. Among them, kinase modulators have been a primary focus for use in cancer treatment. Cellular senescence is believed to protect cells from tumorigenesis by irreversibly halting cell cycle progression and avoiding the growth of damaged cells and tissues. Senescence can also contribute to tumor suppression and be utilized as a mechanism by anti-cancer agents. Although the role of kinase modulators in cancer treatment and their effects on senescence in tumor development have been extensively studied, the relationship between kinase modulators for cancer treatment and senescence has not been fully discussed. In this review, we discuss the pro- and anti-tumorigenesis functions of senescence and summarize the key roles of kinase modulators in the regulation of senescence against tumors
- Subjects
KINASE inhibitors; IMMUNOGLOBULINS; PULMONARY fibrosis; CANCER treatment; RHEUMATOID arthritis
- Publication
Molecules, 2017, Vol 22, Issue 9, p1411
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules22091411