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- Title
Ionic Liquid as an Efficient Medium for the Synthesis of Quinoline Derivatives via α-Chymotrypsin-Catalyzed Friedländer Condensation.
- Authors
Zhang-Gao Le; Meng Liang; Zhong-Sheng Chen; Sui-Hong Zhang; Zong-Bo Xie
- Abstract
An efficient, convenient, and eco-friendly biocatalytic approach was developed for the synthesis of quinoline derivatives via the α-chymotrypsin-catalyzed Friedländer reaction. Interestingly, α-chymotrypsin exhibited higher catalytic activity in an ionic liquid (IL) aqueous solution as compared to that observed in our previous relevant study, which was conducted using an organic solvent, and a series of substrates gave similar excellent yields at lower reaction temperature and under reduced enzyme-loading conditions.
- Subjects
QUINOLINE derivatives; IONIC liquids; CHYMOTRYPSIN; ORGANIC solvents; ENZYMES
- Publication
Molecules, 2017, Vol 22, Issue 5, p762
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules22050762