We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Pharmacological Activities and Synthesis of Esculetin and Its Derivatives: A Mini-Review.
- Authors
Chengyuan Liang; Weihui Ju; Shaomeng Pei; Yonghong Tang; Yadong Xiao
- Abstract
Esculetin, synonymous with 6,7-dihydroxycoumarin, is the main active ingredient of the traditional Chinese medicine Cortex Fraxini. The twig skin or trunk bark of Cortex Fraxini are used by herb doctors as a mild, bitter liver and gallbladder meridians’ nontoxic drug as well as dietary supplement. Recently, with a variety of novel esculetin derivatives being reported, the molecular mechanism research as well as clinical application of Cortex Fraxini and esculetin are becoming more attractive. This mini-review will consolidate what is known about the biological activities, the mechanism of esculetin and its synthetic derivatives over the past decade in addition to providing a brief synopsis of the properties of esculetin.
- Publication
Molecules, 2017, Vol 22, Issue 3, p387
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules22030387