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- Title
Effect of Culture Conditions on Metabolite Production of Xylaria sp.
- Authors
Hongqi Zhang; Zhangshuang Deng; Zhiyong Guo; Yan Peng; Nianyu Huang; Haibo He; Xuan Tu; Kun Zou
- Abstract
Seeking a strategy for triggering the cryptic natural product biosynthesis to yield novel compounds in the plant-associated fungus Xylaria sp., the effect of culture conditions on metabolite production was investigated. A shift in the production of five known cytochalasin-type analogues 1-5 to six new α-pyrone derivatives, xylapyrones A-F (compounds 6-11), from a solid to a liquid medium was observed. These compounds were identified by analysis of 1D and 2D NMR and HRMS data. Compounds 1-3 showed moderate cytotoxicity against HepG2 and Caski cancer cell lines with IC50 values ranging from 25 to 63 μM and compounds 4-11 were found to be inactive, with ICY50 values >100 μM.
- Subjects
XYLARIA; NATURAL products; CYTOCHALASINS; PLANT metabolites; CELL-mediated cytotoxicity
- Publication
Molecules, 2015, Vol 20, Issue 5, p7940
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules20057940