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- Title
Efficient Synthesis and Anti-Fungal Activity of Oleanolic Acid Oxime Esters.
- Authors
Hanqing Zhao; Minjie Zhou; Lifeng Duan; Wei Wang; Jianjun Zhang; Daoquan Wang; Xiaomei Liang
- Abstract
In order to develop potential glucosamine-6-phosphate synthase inhibitors and anti-fungal agents, twenty five oleanolic acid oxime esters were synthesized in an efficient way. The structures of the new compounds were confirmed by MS, HRMS, 1H-NMR and 13C-NMR. Preliminary studies based on means of the Elson-Morgan method indicated that many compounds exhibited some inhibitory activity of glucosamine-6-phosphate synthase (GlmS), and the original fungicidal activities results showed that some of the compounds exhibited good fungicidal activities towards Sclerotinia sclerotiorum (Lib.) de Bary, Rhizoctonia solani Kuhn and Botrytis cinerea Pers at the concentration of 50 μg/mL. These compounds would thus merit further study and development as antifungal agents.
- Subjects
ANTIFUNGAL agents; GLUCOSAMINE synthase; CHEMICAL synthesis; PHOSPHATES; SCLEROTINIA sclerotiorum; RHIZOCTONIA solani; BOTRYTIS cinerea
- Publication
Molecules, 2013, Vol 18, Issue 3, p3615
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules18033615