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- Title
Trypanocidal Activity of Oxoaporphine and Pyrimidine-β-Carboline Alkaloids from the Branches of Annona foetida Mart. (Annonaceae).
- Authors
Costa, Emmanoel Vilaça; Belém Pinheiro, Maria Lúcia; Leão de Souza, Afonso Duarte; Barison, Andersson; Campos, Francinete Ramos; Valdez, Rodrigo Hinojosa; Ueda-Nakamura, Tânia; Dias Filho, Benedito Prado; Nakamura, Celso Vataru
- Abstract
Phytochemical investigation of the branches of Annona foetida Mart. led to isolation from the CH2Cl2 extract of four alkaloids: Atherospermidine (1), described for the first time in this species, liriodenine (2), O-methylmoschatoline (3), and annomontine (4). Their chemical structures were established on the basis of spectroscopic data from IR, MS, NMR (1D and 2D), and comparison with the literature. Compounds 2-4 showed potent trypanocidal effect when evaluated against epimastigote and trypomastigote forms of Trypanosoma cruzi.
- Subjects
PYRIMIDINES; CARBOLINES; ALKALOIDS; ANNONA; TRYPANOSOMA cruzi
- Publication
Molecules, 2011, Vol 16, Issue 11, p9714
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules16119714