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- Title
Microevolution and independent incursions as main forces shaping H5 Hemagglutinin diversity during a H5N8/H5N5 highly pathogenic avian influenza outbreak in Czech Republic in 2017.
- Authors
Nagy, Alexander; Dán, Ádám; Černíková, Lenka; Vitásková, Eliška; Křivda, Vlastimil; Horníčková, Jitka; Masopust, Roman; Sedlák, Kamil
- Abstract
Here, we present a comprehensive analysis of the H5N8/H5N5 highly pathogenic avian influenza (HPAI) virus strains detected in the Czech Republic during an outbreak in 2017. Network analysis of the H5 Hemagglutinin (HA) from 99% of the outbreak localities suggested that the diversity of the Czech H5N8/H5N5 viruses was influenced by two basic forces: local microevolution and independent incursions. The geographical occurrence of the central node H5 HA sequences revealed three eco-regions, which apparently played an important role in the origin and further spread of the local H5N8/HPAI variants across the country. A plausible explanation for the observed pattern of diversity is also provided.
- Subjects
MICROEVOLUTION; HEMAGGLUTININ; AVIAN influenza; MICROBIAL virulence; DISEASE outbreaks
- Publication
Archives of Virology, 2018, Vol 163, Issue 8, p2219
- ISSN
0304-8608
- Publication type
Article
- DOI
10.1007/s00705-018-3833-7