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- Title
Hypercapnia and Hypoxia Stimulate Proliferation of Astrocytes and Neurons In Vitro.
- Authors
Tregub, P. P.; Morgun, A. V.; Osipova, E. D.; Kulikov, V. P.; Malinovskaya, N. A.; Kuzovkov, D. A.
- Abstract
We compared proliferative activity and hypoxic tolerance in a co-culture of neurons and astrocytes in vitro after preliminary exposure to normobaric hypoxia and/or permissive hypercapnia in vivo. Preliminary hypoxic exposure increased the cell index throughout the 72-h period of observation, the effect of hypercapnia was observed on days 1 and 3 of the experiment, and the effect of hypercapnic hypoxia was noted only on day 1. Preliminary hypoxic exposure has a protective effect on nerve cells under conditions of chemical hypoxia. This suggests that hypercapnia and hypoxia activate proliferative activity of nerve cells, which can be viewed as a mechanism of their neuroprotective effectiveness.
- Subjects
HYPERCAPNIA; HYPOXEMIA; NEURONS
- Publication
Bulletin of Experimental Biology & Medicine, 2020, Vol 169, Issue 6, p755
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-020-04972-w