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- Title
Evaluation of familial Mediterranean fever patients concomitant with juvenile spondyloarthropathy.
- Authors
Kısaarslan, Ayşenur Paç; Şahin, Nihal; Çiçek, Sümeyra Özdemir; Gündüz, Zübeyde; Poyrazoğlu, Hakan; Düşünsel, Ruhan
- Abstract
Objectives: Familial Mediterranean fever (FMF) may present with various concomitant diseases. This study aims to evaluate the clinical characteristics of patients with FMF with Juvenile Spondyloarthropathy (jSpA). Method: Thirty-two patients diagnosed with FMF/jSpA, sixty-four with FMF, and fifty-four with jSpA were included in this retrospective study. Three patient groups were compared in terms of clinical and laboratory features. Results: The mean ages of patients in the FMF/jSpA, FMF and jSpA groups were 15.75(11.50-19.83), 15,41(6.83-21.50), and 16(9-22) years, respectively. Chronic arthritis (OR: 0.11, p=.049), erythrocyte sedimentation rate values (OR:1.07, p=.011), and C-reactive protein values (OR:1,08, p: .039) of the patients in remission period were found higher, the international severity scores for FMF (ISSF) before and after colchicine treatment (OR: 1.16, p: .021, OR: 2,21, p: .012) were higher in the FMF/jSpA group compared to FMF. Plantar fasciitis was more common and HLA-B27 positivity rate was lower in the FMF/jSpA group (OR:0.08, p=.024), (OR:4.71, p¼.002) compared to jSpA. FMF/jSpA patients were divided as previous diagnosed FMF and jSpA.The diagnosis of jSpA was at a younger age(p=.002), Juvenile arthritis damage index-articular(p=0.022) and extraarticular(p=.026), and the rate of biologic drug usage (p=.015) were higher in the previous jSpA group. The number of FMF attacks before colchicine was lower in the previous jSpA group (p=.02). Conclusion: Our findings suggest that both classical FMF and jSpA findings were lower in patients with FMF/jSpA. Patients who were diagnosed with jSpA at an early age and who had enthesitis and plantar fasciitis should also be evaluated in terms of FMF.
- Subjects
FAMILIAL Mediterranean fever; JOINT diseases; PLANTAR fasciitis; ARTHRITIS; BLOOD sedimentation
- Publication
Modern Rheumatology, 2021, Vol 31, Issue 3, p718
- ISSN
1439-7595
- Publication type
Article
- DOI
10.1080/14397595.2020.1812809