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- Title
HTLV-I virological and histopathological analysis in two cases of anti-centromere-antibody-seropositive Sjögren's syndrome.
- Authors
Nakamura, Hideki; Horai, Yoshiro; Tokuyama, Ayuko; Yoshimura, Shunsuke; Nakajima, Hideki; Ichinose, Kunihiro; Yamasaki, Satoshi; Nakamura, Tatsufumi; Hayashi, Tomayoshi; Kawakami, Atsushi
- Abstract
Introduction: The aim of this study was to show the clinical and pathological characteristics of anti-centromere-antibody (ACA)-seropositive Sjögren's syndrome (SS) in two anti-human T-cell leukemia virus type I (HTLV-I)-seropositive patients. Methods: One patient was an HTLV-I carrier whereas the other was diagnosed with HTLV-I-associated myelopathy (HAM). Background data including serum HTLV-I titers, viral loads, and cytokine profiles were recorded. Azocarmine with aniline blue (Azan)-Mallory staining and immunohistochemistry of the labial salivary glands (LSGs) and a muscle biopsy specimen from the HAM patient were performed. Results: Serum transforming growth factor beta (TGF-β), tumor necrosis factor alpha (TNF-α), and HTLV-I viral load were high in the HAM-SS patient compared with the HTLV-I carrier. Fibrous change in LSG was prominent in the HAM-SS patient. Although TGF-β expression was similar in the two patients, expression of HTLV-I-related proteins including p12, p28, group-specific antigen (GAG), and nuclear factor kappa-B (NF-κB) in the LSG were dominantly detected in the HAM-SS patient. Frequency of TGF-β staining in HTLV-I-seropositive SS patients without ACA, HTLV-I-seronegative SS patients with ACA, and HTLV-I-seronegative SS patients without ACA was lower than that of the previous two patients. Conclusion: A high HTLV-I viral load in situ is supposed to promote the production of cytokines, especially TGF-β, resulting in the fibrous change of LSG in ACA-seropositive SS patients.
- Subjects
HTLV-I; VIROLOGY; HISTOPATHOLOGY; CENTROMERE; IMMUNOGLOBULINS; CYTOKINES; TRANSFORMING growth factors; SJOGREN'S syndrome
- Publication
Modern Rheumatology, 2013, Vol 23, Issue 1, p133
- ISSN
1439-7595
- Publication type
Article
- DOI
10.3109/s10165-012-0641-x