We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
MRS in Early and Presymptomatic Carriers of a Novel Octapeptide Repeat Insertion in the Prion Protein Gene.
- Authors
McDade, Eric M; Boeve, Bradley F.; Fields, Julie A; Kumar, Neeraj; Rademakers, Rosa; Baker, Matt C.; Knopman, BSc, David S.; Petersen, Ronald C.; Jack, Clifford R.; Kantarci, Kejal
- Abstract
ABSTRACT To evaluate the proton magnetic resonance (MR) spectroscopy (1H MRS) changes in carriers of a novel octapeptide repeat insertion in the prion protein gene (PRNP) and family history of frontotemporal dementia with ataxia. Four at-risk mutation carriers and 13 controls were compared using single voxel, short TE, 1H MRS from the posterior cingulate gyrus. The mutation carriers had an increased choline/creatine, P= .003 and increased myoinositol/creatine ratio, P= .003. 1H MRS identified differences in markers of glial activity and choline metabolism in pre- and early-symptomatic carriers of a novel PRNP gene octapeptide insertion. These findings expand the possible diagnostic utility of 1H MRS in familial prion disorders.
- Subjects
PEPTIDES; PROTON magnetic resonance spectroscopy; PRIONS; ATAXIA; FRONTOTEMPORAL dementia; CREATINE; PROTEIN genetics
- Publication
Journal of Neuroimaging, 2013, Vol 23, Issue 3, p409
- ISSN
1051-2284
- Publication type
Article
- DOI
10.1111/j.1552-6569.2012.00717.x