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- Title
Biotransformation of lantadene A (22beta-angeloyloxy-3-oxoolean-12-en-28-oic acid), the pentacyclic triterpenoid, by Alcaligenes faecalis
- Authors
Singh, A.; Sharma, O. P.; Kanwar, S. S.; Mahato, S. B.; Dawra, R. K.
- Abstract
A bacterial strain capable of biotransformation of lantadene A (22beta -angeloyloxy-3-oxo-olean-12-en-28-oic acid), the pentacyclic hepatotoxin of lantana ( Lantana camara var. aculeata) has been isolated from soil using lantadene A as the sole carbon source. The organism isGram negative, rod shaped, motile, catalase positive and has been identified as Alcaligenes faecalis. The isolate has been found to be specific for lantadene A and did not utilize lantadene B. In studies using sucrose as an additional carbon source, A. faecalis elicited biotransformation of lantadene A to its trans isomer 22 beta -tigloyloxy-3-oxoolean-12-en-28-oic acid, designated as lantadene X and two otherminor metabolites which could not be isolated in pure state.
- Subjects
BIODEGRADATION; BIOTRANSFORMATION (Metabolism)
- Publication
Biodegradation, 1999, Vol 10, Issue 5, p373
- ISSN
0923-9820
- Publication type
Article
- DOI
10.1023/a:1008310511539