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- Title
Generating a Wnt switch: it's all about the right dosage.
- Authors
Kestler, Hans A.; Kühl, Michael
- Abstract
Wnt proteins can activate different branches of the Wnt signaling pathway, raising the question of specificity. In this issue, Nalesso et al. (2011. J. Cell Biol. doi:10.1083/jcb.201011051) provide an answer to this conundrum by showing that different concentrations of Wnt ligands can elicit different intracellular responses. These findings not only provide new insights into the molecular mechanisms underlying Wnt signaling, but also indicate how Wnt gradients might contribute to tissue patterning during embryogenesis.
- Subjects
PROTEINS; WNT proteins; BIOMOLECULES; LIGANDS (Biochemistry); EMBRYOLOGY
- Publication
Journal of Cell Biology, 2011, Vol 193, Issue 3, p431
- ISSN
0021-9525
- Publication type
Article
- DOI
10.1083/jcb.201103167