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- Title
MT1- MMP -- dependent neovessel Formation within the confines of the three-dimensional extracellular matrix.
- Authors
Tae-Hwa Chun; Sabeh, Farideh; Ota, Ichiro; Murphy, Hedwig; McDonagh, Kevin T.; Holmbeck, Kenn; Birkedal-Hansen, Henning; Allen, Edward D.; Weiss, Stephen J.
- Abstract
This article presents a study which shows that MT1-MMP dependent neovessel formation within the confines of the three-dimensional extracellular matrix. Angiogenesis is a specialized form of branching morphogenesis wherein endothelial cells detach themselves from the existing vasculature, invade surrounding tissues, and reorganize into patent tubules. Although the triple-helical molecule is resistant to almost all forms of proteolytic attack, endothelial cells engaged in the angiogenic process are believed to negotiate this structural barrier by mobilizing proteolytic cascades that converge on the matrix metalloproteinases progelatinase A and progelatinase.
- Subjects
NEOVASCULARIZATION; ORGANS (Anatomy); CONNECTIVE tissues; EXTRACELLULAR matrix; BLOOD vessels; INTELLECTUAL property; METALLOENZYMES
- Publication
Journal of Cell Biology, 2004, Vol 167, Issue 4, p757
- ISSN
0021-9525
- Publication type
Article
- DOI
10.1083/jcb.200405001