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- Title
Clinical Features and Molecular Characteristics of Methicillin-Susceptible Staphylococcus aureus Ocular Infection in Taiwan.
- Authors
Chen, Yueh-Ling; Kang, Eugene Yu-Chuan; Yeh, Lung-Kun; Ma, David H. K.; Tan, Hsin-Yuan; Chen, Hung-Chi; Hung, Kuo-Hsuan; Huang, Yhu-Chering; Hsiao, Ching-Hsi
- Abstract
This study analyzed the clinical features and molecular characteristics of methicillin-susceptible Staphylococcus aureus (MSSA) ocular infections in Taiwan and compared them between community-associated (CA) and health-care-associated (HA) infections. We collected S. aureus ocular isolates from patients at Chang Gung Memorial Hospital between 2010 and 2017. The infections were classified as CA or HA using epidemiological criteria, and the isolates were molecularly characterized using pulsed-field gel electrophoresis, multilocus sequence typing, and Panton-Valentine leukocidin (PVL) gene detection. Antibiotic susceptibility was evaluated using disk diffusion and an E test. A total of 104 MSSA ocular isolates were identified; 46 (44.2%) were CA-MSSA and 58 (55.8%) were HA-MSSA. Compared with HA-MSSA strains, CA-MSSA strains caused a significantly higher rate of keratitis, but a lower rate of conjunctivitis. We identified 14 pulsotypes. ST 7/pulsotype BA was frequently identified in both CA-MSSA (28.3%) and HA-MSSA (37.9%) cases. PVL genes were identified in seven isolates (6.7%). Both CA-MSSA and HA-MSSA isolates were highly susceptible to vancomycin, teicoplanin, tigecycline, sulfamethoxazole–trimethoprim, and fluoroquinolones. The most common ocular manifestations were keratitis and conjunctivitis for CA-MSSA and HA-MSSA, respectively. The MSSA ocular isolates had diverse molecular characteristics; no specific genotype differentiated CA-MSSA from HA-MSSA. Both strains exhibited similar antibiotic susceptibility.
- Subjects
TAIWAN; STAPHYLOCOCCUS aureus infections; PULSED-field gel electrophoresis; TEICOPLANIN; TIGECYCLINE; OCULAR manifestations of general diseases
- Publication
Antibiotics (2079-6382), 2021, Vol 10, Issue 12, p1445
- ISSN
2079-6382
- Publication type
Article
- DOI
10.3390/antibiotics10121445