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- Title
Two Strategies for the Dosage of Acenocoumarol Co-Administered with Rifampicin in Staphylococcal Prosthetic Valve Endocarditis.
- Authors
Wełnicki, Marcin; Buksińska-Lisik, Małgorzata; Mamcarz, Artur
- Abstract
According to current European Society of Cardiology guidelines, for staphylococcal prosthetic valve endocarditis, rifampicin should be one of the drugs used. However, there is a concomitant need for vitamin K antagonists in patients with mechanical prostheses. It is widely known that rifampicin interacts with vitamin K antagonists (VKA), and this interaction makes it difficult to maintain the INR (international normalized ratio) value in the therapeutic range. We present two clinical cases of staphylococcal prosthetic valve endocarditis patients. Two different strategies for dealing with adverse drug interactions have been applied. In the first case, the dose of warfarin was up-titrated until the optimal INR value was obtained. In the second case, due to the history of labile INR values, a decision was made to modify the dosage of warfarin, taking into account pharmacological aspects of drug interactions.
- Subjects
EUROPEAN Society of Cardiology; ANTICOAGULANTS; RIFAMPIN; ENDOCARDITIS; INFECTIVE endocarditis; DRUG interactions; INTERNATIONAL normalized ratio
- Publication
Antibiotics (2079-6382), 2021, Vol 10, Issue 1, p38
- ISSN
2079-6382
- Publication type
Article
- DOI
10.3390/antibiotics10010038