We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Inhibition of atopic dermatitis-like skin lesions by topical application of a novel ceramide derivative, K6PC-9p, in NC/Nga mice.
- Authors
Jong Soon Kang; Won Kee Yoon; Jong-Kyung Youm; Se Kyoo Jeong; Byeong Deog Park; Mi Hwa Han; Hyunju Lee; Eun-Yi Moon; Sang-Bae Han; Chang Woo Lee; Kiho Lee; Song-Kyu Park; Kyu-Hwan Yang; Hwan Mook Kim
- Abstract
Atopic dermatitis (AD) is a chronic inflammatory skin disease that commonly begins in childhood. K6PC-9p ( N-(Ethyl dihydrogenphosphate)-2-hexyl-3-oxo-decanamide) is a synthetic ceramide derivative of PC-9S ( N-Ethanol-2-mirystyl-3-oxo-staramide), which was known to be effective in atopic patients. In this study, we examined the effect of topical application of K6PC-9p on skin inflammation and AD-like skin lesions in mouse models. K6PC-9p dose-dependently inhibited phorbol ester-induced increase in ear thickness in BALB/c mice. Moreover, topical application of K6PC-9p suppressed dust mite extract-induced AD-like skin lesions in NC/Nga mice. Histopathological analysis revealed that both ear swelling and leucocyte infiltration were suppressed by K6PC-9p treatment. K6PC-9p also suppressed IL-4 and TNF-α expression in the ears and mast cell infiltration into the ears in NC/Nga mice. Further study demonstrated that K6PC-9p inhibited ConA-induced IL-4 secretion and LPS-induced macrophage activation. Taken together, our results showed that topical application of K6PC-9p exerts beneficial effects in animal model of skin inflammation and AD, suggesting that K6PC-9p might be a promising topical agent for the treatment of inflammatory skin diseases.
- Subjects
ATOPIC dermatitis; CERAMIDES; SKIN inflammation; LEUCOCYTES; MICE
- Publication
Experimental Dermatology, 2008, Vol 17, Issue 11, p958
- ISSN
0906-6705
- Publication type
Article
- DOI
10.1111/j.1600-0625.2008.00737.x