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Potent inhibitors of toxic alpha-synuclein identified via cellular time-resolved FRET biosensors.
- Published in:
- NPJ Parkinson's Disease, 2021, v. 7, n. 1, p. 1, doi. 10.1038/s41531-021-00195-6
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- Publication type:
- Article
Trans-synaptic and retrograde axonal spread of Lewy pathology following pre-formed fibril injection in an in vivo A53T alpha-synuclein mouse model of synucleinopathy.
- Published in:
- Acta Neuropathologica Communications, 2020, v. 8, n. 1, p. N.PAG, doi. 10.1186/s40478-020-01026-0
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- Publication type:
- Article
Poly (ADP-ribose) Interacts With Phosphorylated α-Synuclein in Post Mortem PD Samples.
- Published in:
- Frontiers in Aging Neuroscience, 2021, v. 13, p. 1, doi. 10.3389/fnagi.2021.704041
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- Publication type:
- Article
Differentially targeted seeding reveals unique pathological alpha-synuclein propagation patterns.
- Published in:
- 2022
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- Publication type:
- journal article
Dopamine neurons exhibit emergent glutamatergic identity in Parkinson's disease.
- Published in:
- 2022
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- Publication type:
- journal article
Intrastriatal alpha-synuclein fibrils in monkeys: spreading, imaging and neuropathological changes.
- Published in:
- 2019
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- Publication type:
- journal article
Glutamate Promotes Proliferation of Striatal Neuronal Progenitors by an NMDA Receptor-Mediated Mechanism.
- Published in:
- Journal of Neuroscience, 2003, v. 23, n. 6, p. 2239, doi. 10.1523/JNEUROSCI.23-06-02239.2003
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- Publication type:
- Article
Epidemiological spread models of Parkinson’s disease support the prion‐like role of alpha‐synuclein.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, p. 1, doi. 10.1002/alz.051670
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- Publication type:
- Article
Snca-GFP Knock-In Mice Reflect Patterns of Endogenous Expression and Pathological Seeding.
- Published in:
- eNeuro, 2020, v. 7, n. 4, p. 1, doi. 10.1523/ENEURO.0007-20.2020
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- Publication type:
- Article
α-Synuclein aggregates amplified from patient-derived Lewy bodies recapitulate Lewy body diseases in mice.
- Published in:
- Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-42705-5
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- Publication type:
- Article
Identification of a Putative α-synuclein Radioligand Using an in silico Similarity Search.
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- Molecular Imaging & Biology, 2023, v. 25, n. 4, p. 704, doi. 10.1007/s11307-023-01814-9
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- Publication type:
- Article
Cell Culture Media, Unlike the Presence of Insulin, Affect α-Synuclein Aggregation in Dopaminergic Neurons.
- Published in:
- Biomolecules (2218-273X), 2022, v. 12, n. 4, p. 563, doi. 10.3390/biom12040563
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- Publication type:
- Article
Alpha-synuclein inclusion responsive microglia are resistant to CSF1R inhibition.
- Published in:
- Journal of Neuroinflammation, 2024, v. 21, n. 1, p. 1, doi. 10.1186/s12974-024-03108-5
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- Publication type:
- Article
Alpha-synuclein is a DNA binding protein that modulates DNA repair with implications for Lewy body disorders.
- Published in:
- Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-47227-z
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- Publication type:
- Article
Investigating key factors underlying neurodegeneration linked to alpha‐synuclein spread.
- Published in:
- Neuropathology & Applied Neurobiology, 2022, v. 48, n. 6, p. 1, doi. 10.1111/nan.12829
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- Publication type:
- Article
Synthetic alpha-synuclein fibrils cause mitochondrial impairment and selective dopamine neurodegeneration in part via iNOS-mediated nitric oxide production.
- Published in:
- Cellular & Molecular Life Sciences, 2017, v. 74, n. 15, p. 2851, doi. 10.1007/s00018-017-2541-x
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- Publication type:
- Article
A Connection Between DNA Repair Protein APE1, Alpha‐Synucleinopathy, and Biological Sex in Rodents and Humans.
- Published in:
- FASEB Journal, 2022, v. 36, p. N.PAG, doi. 10.1096/fasebj.2022.36.S1.R3221
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- Publication type:
- Article
Oxidative stress and α-synuclein conspire in vulnerable neurons to promote Parkinson's disease progression.
- Published in:
- 2019
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- Publication type:
- journal article
Transcriptomic profiling of early synucleinopathy in rats induced with preformed fibrils.
- Published in:
- NPJ Parkinson's Disease, 2024, v. 10, n. 1, p. 1, doi. 10.1038/s41531-023-00620-y
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- Publication type:
- Article
Tau maturation in the clinicopathological spectrum of Lewy body and Alzheimer's disease.
- Published in:
- Annals of Clinical & Translational Neurology, 2024, v. 11, n. 3, p. 673, doi. 10.1002/acn3.51988
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- Publication type:
- Article
Deficits in basal and evoked striatal dopamine release following alpha‐synuclein preformed fibril injection: An in vivo microdialysis study.
- Published in:
- European Journal of Neuroscience, 2024, v. 59, n. 7, p. 1585, doi. 10.1111/ejn.16275
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- Publication type:
- Article
Combining fibril‐induced alpha‐synuclein aggregation and 6‐hydroxydopamine in a mouse model of Parkinson's disease and the effect of cerebral dopamine neurotrophic factor on the induced neurodegeneration.
- Published in:
- European Journal of Neuroscience, 2024, v. 59, n. 1, p. 132, doi. 10.1111/ejn.16196
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- Publication type:
- Article
Neurogenesis and stereological morphometry of calretinin-immunoreactive GABAergic interneurons of the neostriatum.
- Published in:
- Journal of Comparative Neurology, 2004, v. 469, n. 3, p. 325, doi. 10.1002/cne.11008
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- Publication type:
- Article
The center of olfactory bulb‐seeded α‐synucleinopathy is the limbic system and the ensuing pathology is higher in male than in female mice.
- Published in:
- Brain Pathology, 2019, v. 29, n. 6, p. 741, doi. 10.1111/bpa.12718
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- Publication type:
- Article
Measurements of auto‐antibodies to α‐synuclein in the serum and cerebral spinal fluids of patients with Parkinson's disease.
- Published in:
- Journal of Neurochemistry, 2018, v. 145, n. 6, p. 489, doi. 10.1111/jnc.14330
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- Publication type:
- Article
The transcription factor Pitx3 is expressed selectively in midbrain dopaminergic neurons susceptible to neurodegenerative stress.
- Published in:
- Journal of Neurochemistry, 2013, v. 125, n. 6, p. 932, doi. 10.1111/jnc.12160
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- Publication type:
- Article
Correction to: Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration.
- Published in:
- 2018
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- Publication type:
- corrected article
Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration.
- Published in:
- 2018
- By:
- Publication type:
- journal article
Dopaminergic Positron Emission Tomography Imaging in the Alpha‐Synuclein Preformed Fibril Model Reveals Similarities to Early Parkinson's Disease.
- Published in:
- Movement Disorders, 2022, v. 37, n. 8, p. 1739, doi. 10.1002/mds.29051
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- Publication type:
- Article
GDNF/RET Signaling Pathway Activation Eliminates Lewy Body Pathology in Midbrain Dopamine Neurons.
- Published in:
- Movement Disorders, 2020, v. 35, n. 12, p. 2279, doi. 10.1002/mds.28258
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- Publication type:
- Article
Seeding of protein aggregation causes cognitive impairment in rat model of cortical synucleinopathy.
- Published in:
- 2019
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- Publication type:
- journal article
Neuronal vulnerability in Parkinson disease: Should the focus be on axons and synaptic terminals?
- Published in:
- 2019
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- Publication type:
- journal article
Current insights and assumptions on α-synuclein in Lewy body disease.
- Published in:
- Acta Neuropathologica, 2024, v. 148, n. 1, p. 1, doi. 10.1007/s00401-024-02781-3
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- Publication type:
- Article
MSUT2 regulates tau spreading via adenosinergic signaling mediated ASAP1 pathway in neurons.
- Published in:
- Acta Neuropathologica, 2024, v. 147, n. 1, p. 1, doi. 10.1007/s00401-024-02703-3
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- Publication type:
- Article
The variance in phosphorylated, insoluble ⍺-synuclein in humans, rats, and mice is not mainly driven by biological sex.
- Published in:
- Acta Neuropathologica, 2023, v. 146, n. 4, p. 651, doi. 10.1007/s00401-023-02621-w
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- Publication type:
- Article
Neuronal activity modulates alpha-synuclein aggregation and spreading in organotypic brain slice cultures and in vivo.
- Published in:
- Acta Neuropathologica, 2020, v. 140, n. 6, p. 831, doi. 10.1007/s00401-020-02227-6
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- Publication type:
- Article
Differential α-synuclein expression contributes to selective vulnerability of hippocampal neuron subpopulations to fibril-induced toxicity.
- Published in:
- Acta Neuropathologica, 2018, v. 135, n. 6, p. 855, doi. 10.1007/s00401-018-1829-8
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- Publication type:
- Article
Spread of aggregates after olfactory bulb injection of α-synuclein fibrils is associated with early neuronal loss and is reduced long term.
- Published in:
- Acta Neuropathologica, 2018, v. 135, n. 1, p. 65, doi. 10.1007/s00401-017-1792-9
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- Publication type:
- Article
Bent out of shape: α-Synuclein misfolding and the convergence of pathogenic pathways in Parkinson’s disease.
- Published in:
- FEBS Letters, 2015, v. 589, n. 24PartA, p. 3749, doi. 10.1016/j.febslet.2015.10.023
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- Publication type:
- Article
Erratum to: Transmission of α- synucleinopathy from olfactory structures deep into the temporal lobe.
- Published in:
- 2016
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- Publication type:
- Correction Notice
Transmission of α-synucleinopathy from olfactory structures deep into the temporal lobe.
- Published in:
- Molecular Neurodegeneration, 2016, v. 11, p. 1, doi. 10.1186/s13024-016-0113-4
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- Publication type:
- Article
Striatal Afferent BDNF Is Disrupted by Synucleinopathy and Partially Restored by STN DBS.
- Published in:
- Journal of Neuroscience, 2021, v. 41, n. 9, p. 2039, doi. 10.1523/JNEUROSCI.1952-20.2020
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- Publication type:
- Article
α-Synuclein arginylation in the human brain.
- Published in:
- Translational Neurodegeneration, 2022, v. 11, n. 1, p. 1, doi. 10.1186/s40035-022-00295-0
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- Publication type:
- Article
Addition of exogenous α-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous α-synuclein to Lewy body and Lewy neurite–like aggregates.
- Published in:
- Nature Protocols, 2014, v. 9, n. 9, p. 2135, doi. 10.1038/nprot.2014.143
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- Publication type:
- Article
Group I mGluR5 metabotropic glutamate receptors regulate proliferation of neuronal progenitors in specific forebrain developmental domains.
- Published in:
- Journal of Neurochemistry, 2008, v. 104, n. 1, p. 155, doi. 10.1111/j.1471-4159.2007.04955.x
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- Publication type:
- Article
Positron Emission Tomography with [ 18 F]ROStrace Reveals Progressive Elevations in Oxidative Stress in a Mouse Model of Alpha-Synucleinopathy.
- Published in:
- International Journal of Molecular Sciences, 2024, v. 25, n. 9, p. 4943, doi. 10.3390/ijms25094943
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- Publication type:
- Article
Focal ultrasound strikes a new tune for targeted drug delivery.
- Published in:
- 2018
- By:
- Publication type:
- Editorial
Developmental exposure to the Parkinson's disease-associated organochlorine pesticide dieldrin alters dopamine neurotransmission in α-synuclein pre-formed fibril (PFF)-injected mice.
- Published in:
- Toxicological Sciences, 2023, v. 196, n. 1, p. 99, doi. 10.1093/toxsci/kfad086
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- Publication type:
- Article
Glutamate and Regulation of Proliferation in the Developing Mammalian Telencephalon.
- Published in:
- Developmental Neuroscience, 2004, v. 26, n. 2-4, p. 218, doi. 10.1159/000082139
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- Publication type:
- Article