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- Title
Adaptation of protein oxidation to protein intake in the domestic cat.
- Authors
Green, A. S.; Ramsey, J. J.; Villaverde, C.; Asami, D.; Fascetti, A. J.
- Abstract
It is well-accepted that cats require more dietary protein than omnivores and herbivores. Work on hepatic enzyme activities showed that cats lack the ability to regulate the urea cycle enzymes in response to the dietary supply of protein. It was thus hypothesized that the high protein requirement of cats is due to an inability to regulate these enzymes, limiting adaptation to a low protein diet. We used indirect respiration calorimetry to assess the in vivo ability of cats to adapt substrate oxidation to different levels of dietary protein, including one below their protein requirement. In random order, eight cats consumed each of four semi-purified diets containing 7.7% (LP), 14.6% (AP), 27.3% (MP) and 51.1% (HP) of ME from protein. Cats consumed each diet for at least 14 days and then completed a 5-day nitrogen balance trial and at least 2, 12-hour indirect calorimetry measurements. The data were analyzed byanova using the Mixed procedure of SAS and are expressed as mean ± SEM. There was a significant effect of diet on protein oxidation (p < 0.0001), measuring 9.8 ± 0.5%, 13.4 ± 0.9%, 23.5 ± 0.8% and 49.0 ± 1.8% of total energy expenditure on the LP, AP, MP and HP diets, respectively. The ratio of protein oxidation/protein intake was significantly higher with the LP diet (1.27 ± 0.07) than the other three diets (AP, 0.92 ± 0.06; MP, 0.86 ± 0.03; HP, 0.96 ± 0.04; p < 0.0001), indicating a net loss of protein on the LP diet. Thus, cats adapted to a wide range of dietary protein concentrations, but were unable to fully adapt to the LP diet.
- Subjects
LOW-protein diet; INDIRECT calorimetry; ENZYMOLOGY; CATALYSTS; VITAL signs
- Publication
Journal of Animal Physiology & Animal Nutrition, 2008, Vol 92, Issue 2, p219
- ISSN
0931-2439
- Publication type
Article
- DOI
10.1111/j.1439-0396.2007.00789_2.x