We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Pemetrekset'in in vitro Alkali Tek Hücre Jel Elektroforez Yöntemi ile Genotoksik Potansiyelinin Değerlendirilmesi.
- Authors
Çobanoğlu, Hayal; Coşkun, Münevver; Coşkun, Mahmut; Çayır, Akın
- Abstract
Pemetrexed is a chemotherapeutic drug, approved for the treatment of mesothelioma and non–small cell lung cancer and variety of neoplasm. Chemotherapeutic drugs don't target only cancer cells in treatment. During treatment these drugs encounter with normal cells as well. Therefore, in this in vitro study, it was aimed to investigate the whether genotoxic effect or not of Pemetrexed on normal leukocytes. In vitro alkaline comet assay was used in this study. Leukocytes from human peripheral blood samples from two volunteer donors were used in the study. In the present study, leukocytes were treated with four different concentrations (25, 50, 75, and 100 μg/ml) of the drug for 1 hour. At concentration of 75 μg/ml and 100 μg/ml, there were statistically significant increases in DNA damage compared to the negative control (p˂0.05, and p˂0.01 respectively). The obtained result shows that Pemetrexed may have genotoxic potential on normal leucocytes.
- Publication
Marmara Pharmaceutical Journal, 2017, Vol 21, Issue 3, p544
- ISSN
1309-0801
- Publication type
Article
- DOI
10.12991/marupj.318635