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- Title
Titanium complexes bearing 2,6‐bis(o‐hydroxyalkyl)pyridine ligands in vitro cytotoxicity against triple‐negative breast‐cancer cells.
- Authors
Chen, I‐Ni; Ganta, Prasanna Kumar; Chung, Shou‐Jie; Chang, Yu‐Lun; Chang, Heng‐Yi; Ding, Shangwu; Chen, Hsuan‐Ying; Chiu, Chien‐Chih; Wu, Kuo‐Hui
- Abstract
Three titanium (Ti) compounds bearing 2,6‐bis(o‐hydroxyalkyl)pyridine ligands were synthesized, and used in vitro cytotoxicity against triple‐negative breast cancer (TNBC) MDA‐MB‐231 cells was studied. The results of in vitro cytotoxicity of the complexes against TNBC cells revealed that (HLMeTi‐O)4 (IC50 = 0.91 μM) exerted a significant inhibitory effect on the proliferation of TNBC cells. Thus, titanium alkoxide complexes as nonplatinum complex could be used for structural optimization for treating breast cancer cells in the future.
- Subjects
BREAST cancer; TRIPLE-negative breast cancer; TITANIUM; PYRIDINE; LIGANDS (Chemistry); ORGANOPLATINUM compounds
- Publication
Journal of the Chinese Chemical Society, 2021, Vol 68, Issue 5, p871
- ISSN
0009-4536
- Publication type
Article
- DOI
10.1002/jccs.202000393