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- Title
ADAM33 polymorphisms are associated with aspirin-intolerant asthma in the Japanese population.
- Authors
Sakagami, Takuro; Jinnai, Nobuyoshi; Nakajima, Toshiaki; Sekigawa, Takashi; Hasegawa, Takashi; Suzuki, Eiichi; Inoue, Ituro; Gejyo, Fumitake
- Abstract
Multiple single nucleotide polymorphisms (SNPs) within ADAM33 have been reported to be associated with asthma and bronchial hyper-responsiveness in Caucasian populations. We examined whether these SNPs contribute to a predisposition to asthma, especially aspirin-intolerant asthma (AIA), in the Japanese population. Ten polymorphic sites (ST+4, ST+7, T1, T2, T+1, V-3, V-2, V-1, V4, V5) were genotyped in 102 AIA patients, 282 aspirin-tolerant asthma (ATA) patients and 120 control (CTR) subjects by direct sequencing. Haplotype frequencies were estimated by the expectation-maximization method. Differences in allele and haplotype frequencies among phenotypes were analyzed by the chi-square and permutation tests. ST+7, V-1 and V5 sites in the AIA group were significantly different from those in the ATA group ( P=0.034–0.004) and from those in the CTR group ( P=0.019–0.002). Haplotypes at three sites (ST+7, V-1, and V5) were significantly different in frequency between the AIA and ATA ( P=0.008) or CTR ( P=0.001) groups. Sequence variations in ADAM33 are likely to correlate with susceptibility to AIA in the Japanese population.
- Subjects
JAPAN; CAUCASUS; ASPIRIN; ASTHMA treatment; CHI-squared test; RESPIRATORY diseases; GENETIC polymorphisms; GENETICS of disease susceptibility
- Publication
Journal of Human Genetics, 2007, Vol 52, Issue 1, p66
- ISSN
1434-5161
- Publication type
Article
- DOI
10.1007/s10038-006-0081-6