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- Title
Association of bone mineral density with a dinucleotide repeat polymorphism at the calcitonin (CT) locus.
- Authors
Miyao, M.; Hosoi, T.; Emi, M.; Nakajima, T.; Inoue, S.; Hoshino, S.; Shiraki, M.; Orimo, H.; Ouchi, Y.
- Abstract
Abstract Calcitonin (CT), a calcium-regulating hormone, lowers the calcium level in serum by inhibiting bone resorption. Because CT may play a role in the pathogenesis of osteoporosis, genetic variations in or adjacent to the CT gene may be associated with variations in bone mineral density (BMD). The present study examined the correlation between a dinucleotide (cytosine-adenine; CA) repeat polymorphism at the CT locus and BMD in 311 Japanese postmenopausal women (mean age, 64.1 years). Seven alleles were present in this population; each allele contained 10, 11, 16, 17, 18, 19, or 20 CA repeats. Thus, we designated the respective genotypes A10, A11, A16, A17, A18, A19, and A20. The A10 and A17 alleles were the predominant alleles in the population studied. Z scores (a parameter representing deviation from the age-specific weight-adjusted average BMD) were compared between individuals that possessed one or two alleles of each genotype and those that did not possess the allele. Subjects who possessed one or two Al0 alleles had lower BMD Z scores than those who did not (lumbar 2-4 BMD Z score; -0.148 + 1.23 vs 0.182 + 1.54; P = 0.04). No ...
- Subjects
CALCITONIN; BONE densitometry; GENETICS
- Publication
Journal of Human Genetics, 2000, Vol 45, Issue 6, p346
- ISSN
1434-5161
- Publication type
Article
- DOI
10.1007/s100380070006