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- Title
Molecular cloning, expression, and mapping of a novel human cDNA, GRP17, highly homologous to human gadd45 and murine MyD118.
- Authors
Suzuki, Mikio; Watanabe, Takeshi K.; Fujiwara, Tsutomu; Nakamura, Yusuke; Takahashi, Ei-ichi; Tanigami, A.
- Abstract
Abstract From a human placenta cDNA library, we isolated a novel gene whose predicted product is highly homologous in amino acid sequence to human gadd45 and murine MyD118 proteins (about 55% and 52% identity, respectively). The cDNA clone, designated GRP17 (gadd-related protein, 17kDa), contained a 477-bp open reading frame encoding 159 amino acids. Northern blot analysis revealed strong expression of a 1.35-kb transcript in heart, placenta, liver, skeletal muscle, prostate, testis, and ovary. A 1.7-kb additional transcript was detected in liver. We assigned the GRP17 gene to chromosome 9q22.1-q22.2 by fluorescence in situ hybridization (FISH).
- Subjects
MOLECULAR cloning; ANTISENSE DNA; AMINO acid sequence
- Publication
Journal of Human Genetics, 1999, Vol 44, Issue 5, p300
- ISSN
1434-5161
- Publication type
Article
- DOI
10.1007/s100380050164