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- Title
Serologic Prevalence of Ebola Virus in Equatorial Africa.
- Authors
Steffen, Imke; Kai Lu; Yamamoto, Lauren K.; Hoff, Nicole A.; Mulembakani, Prime; Wemakoy, Emile O.; Muyembe-Tamfum, Jean-Jacques; Ndembi, Nicaise; Brennan, Catherine A.; Hackett Jr., John; Stramer, Susan L.; Switzer, William M.; Saragosti, Sentob; Mbensa, Guy O.; Laperche, Syria; Rimoin, Anne W.; Simmons, Graham; Lu, Kai; Hackett, John Jr
- Abstract
We conducted a serologic survey of 2,430 serum samples collected during 1997-2012 for various studies to determine the prevalence of the hemorrhagic fever virus Ebola virus (EBOV) in equatorial Africa. We screened serum samples for neutralizing antibodies by using a pseudotype microneutralization assay and a newly developed luciferase immunoprecipitation system assay. Specimens seroreactive for EBOV were confirmed by using an ELISA. Our results suggest a serologic prevalence of 2%-3.5% in the Republic of the Congo and the Democratic Republic of the Congo, which have reported outbreaks of infection with EBOV. In addition we detected a seroprevalence of 1.3% in southern Cameroon, which indicated a low risk for exposure in this region.
- Subjects
AFRICA; EBOLA virus; EBOLA virus disease; DISEASE prevalence; RISK exposure; SEROPREVALENCE
- Publication
Emerging Infectious Diseases, 2019, Vol 25, Issue 5, p911
- ISSN
1080-6040
- Publication type
journal article
- DOI
10.3201/eid2505.180115