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- Title
Novel Flavivirus or New Lineage of West Nile Virus, Central Europe.
- Authors
Bakonyi, Tamás; Hubálek, Zdenek; Rudolf, Ivo; Nowotny, Norbert
- Abstract
A fiavivirus (strain 97-103) was isolated from Culex pipens mosquitoes in 1997 following floods in South Moravia, Czech Republic. The strain exhibited close antigenic relationship to West Nile virus (WNV) prototype strain Eg-101 in a cross-neutralization test. In this study, mouse pathogenicity characteristics and the complete nucleotide and putative amino acid sequences of isolate 97-103, named Rabensburg virus (RabV) after a nearby Austrian city, were determined. RabV shares only 75%-77% nucleotide identity and 89%-90% amino acid identity with representative strains of WNV lineages 1 and 2. Another RabV strain (99-222) was isolated in the same location 2 years later; it showed >99% nucleotide identity to strain 97-103. Phylogenetic analyses of RabV, WNV strains, and other members of the Japanese encephalitis virus (JEV) complex clearly demonstrated that RabV is either a new (third) lineage of WNV or a novel fiavivirus of the JEV group.
- Subjects
FLAVIVIRUSES; WEST Nile virus; CULEX; AMINO acid analysis; ENCEPHALITIS
- Publication
Emerging Infectious Diseases, 2005, Vol 11, Issue 2, p225
- ISSN
1080-6040
- Publication type
Article
- DOI
10.3201/eid1102.041028