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- Title
MiR-135a functions as a selective killer of malignant glioma.
- Authors
Wu, S; Lin, Y; Xu, D; Chen, J; Shu, M; Zhou, Y; Zhu, W; Su, X; Qiu, P; Yan, G
- Abstract
Glioma is the most common and fatal primary brain tumor. Thus far, therapeutic strategies to efficiently and specifically antagonize glioma are limited and poorly developed. Here we report that glia-enriched miR-135a, a microRNA that is dramatically downregulated in malignant glioma and correlated with the pathological grading, is capable of inducing mitochondria-dependent apoptosis of malignant glioma by regulating various genes including STAT6, SMAD5 and BMPR2, as well as affecting the signaling pathway downstream. Moreover, this lethal effect is selectively towards malignant glioma cells, but not neurons and glial cells, through a novel mechanism. Our findings suggest an important role of miR-135a in glioma etiology and provide a potential candidate for malignant glioma therapy.
- Subjects
BRAIN tumor treatment; MICRORNA; STAT protein genetics; GLIOMA treatment; GENETIC regulation; CELLULAR signal transduction; NEUROGLIA; ETIOLOGY of cancer
- Publication
Oncogene, 2012, Vol 31, Issue 34, p3866
- ISSN
0950-9232
- Publication type
Article
- DOI
10.1038/onc.2011.551