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- Title
Astragaloside Improves Outcomes of Traumatic Brain Injury in Rats by Reducing Microglia Activation.
- Authors
Yang, Shun-Tai; Lin, Jia-Wei; Chiu, Bi-Ying; Hsu, Yao-Chin; Chang, Ching-Ping; Chang, Cheng-Kuei
- Abstract
Astragaloside (AST) is traditionally prescribed for the prevention and treatment of cerebrovascular diseases. We directly tested the therapeutic effects of AST in a rat model of traumatic brain injury (TBI). One hour after the onset of TBI rats were given Saline (1 ml/kg) or AST (20-80 mg/kg) via i.p. injection. AST causes the attenuation of TBI-induced cerebral contusion, neuronal apoptosis, and neurological motor dysfunction. TBI-induced microglial activation evidenced by the morphological transformation of microglia (or ameboid microglia) and the microglial overexpression of tumor necrosis factor-alpha was reduced by AST. Our results indicate that AST may protect against brain contusion and neuronal apoptosis after TBI by attenuating microglia activation in male rats.
- Subjects
ANALYSIS of variance; ANIMAL behavior; ANIMAL experimentation; BIOLOGICAL assay; BRAIN injuries; IMMUNOHISTOCHEMISTRY; RATS; RESEARCH funding; STATISTICAL sampling; STATISTICS; T-test (Statistics); TUMOR necrosis factors; PLANT extracts; DATA analysis; TREATMENT effectiveness; PRE-tests &; post-tests; DATA analysis software; DESCRIPTIVE statistics
- Publication
American Journal of Chinese Medicine, 2014, Vol 42, Issue 6, p1357
- ISSN
0192-415X
- Publication type
Article
- DOI
10.1142/S0192415X14500852