We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Lower risk of gout in sodium glucose cotransporter 2 (SGLT2) inhibitors versus dipeptidyl peptidase-4 (DPP4) inhibitors in type-2 diabetes.
- Authors
Zhou, Jiandong; Liu, Xuejin; Chou, Oscar Hou-In; Li, Lifang; Lee, Sharen; Wong, Wing Tak; Zhang, Qingpeng; Chang, Carlin; Liu, Tong; Tse, Gary; Jing, Fengshi; Cheung, Bernard Man Yung
- Abstract
Objectives The effects of sodium-glucose cotransporter 2 inhibitors (SGLT2I) vs dipeptidyl peptidase-4 inhibitors (DPP4I) on the risk of new-onset gout remains unknown. This study aims to compare the effects of SGLT2I against DPP4I on gout risks. Methods This was a retrospective population-based cohort study of patients with type-2 diabetes mellitus treated with SGLT2I or DPP4I between 1 January 2015 and 31 December 2020 in Hong Kong. The study outcomes are new-onset gout and all-cause mortality. Propensity score matching (1:1 ratio) between SGLT2I and DPP4I was performed. Univariable and multivariable Cox regression models were conducted. Competing risks models and multiple approaches based on the propensity score were applied. Results This study included 43 201 patients [median age: 63.23 years old (Interquartile range, IQR): 55.21–71.95, 53.74% males; SGLT2I group: n = 16 144; DPP4I group: n = 27 057] with a median follow-up of 5.59 years (IQR: 5.27–5.81 years) since initial drug exposure. The incidence rate of developing gout [Incidence rate (IR): 2.5; 95% CI: 2.2, 2.9] among SGLT2I users was significantly lower than DPP4I users (IR: 5.2; 95% CI: 4.8, 5.8). SGLT2I was associated with 51% lower risks of gout (HR: 0.49; 95% CI: 0.42, 0.58; P -value < 0.0001) and 51% lower risks of all-cause mortality (HR: 0.49; 95% CI: 0.42, 0.58; P -value < 0.0001) after adjusting for significant demographics, past comorbidities, medications and laboratory results. The results remained consistent on competing risk and other propensity score approaches. Conclusions SGLT2I use was associated with lower risks of new gout diagnosis compared with DPP4I use.
- Subjects
HONG Kong (China); STATISTICS; CONFIDENCE intervals; MORTALITY; MULTIVARIATE analysis; HYPOGLYCEMIC agents; RETROSPECTIVE studies; DISEASE incidence; REGRESSION analysis; MANN Whitney U Test; FISHER exact test; RISK assessment; TYPE 2 diabetes; T-test (Statistics); DESCRIPTIVE statistics; SODIUM-glucose cotransporter 2 inhibitors; DATA analysis software; ODDS ratio; GOUT; ENZYME inhibitors; LONGITUDINAL method; PROPORTIONAL hazards models; DISEASE risk factors
- Publication
Rheumatology, 2023, Vol 62, Issue 4, p1501
- ISSN
1462-0324
- Publication type
Article
- DOI
10.1093/rheumatology/keac509