We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
A Study of Antihyperglycemic Activity of Alternanthera Pungens Kunth on Alloxan Induced Diabetic Rats.
- Authors
Mourya, Pramod; Singhal, Rohit; Jain, Neetesh K.
- Abstract
Diabetes mellitus is a metabolic disorder characterized by high blood glucose level. The traditional healers have used this plant as remedy to control blood glucose level. The present study was carried out to investigate hypoglycemic effect of the whole plant of Alternanthera Pungens Kunth against Alloxan induced hyperglycemia in rats. Hyperglycemia was induced by an injection of Alloxan Monohydrate 150 mg/kg (i.p.). After 72 hr, the rats having Blood Glucose Level (BGL) above 150 mg/dl were selected for the investigation. The two different doses of aqueous and ethanolic extracts (200 mg/kg and 400 mg/kg b.w.) were observed for antidiabetic effect. BGL was monitored and compared with Metformin (250 mg/kg). Oral administration of both extracts showed significant (P < 0.05) antihyperglycemic activity in a dose-dependent manner in alloxan-induced diabetic rats. After 21 days of treatment with ethanolic extract at dose of 400 mg/kg, the Blood Glucose Level (BGL) decrease from 268.34 to 104.68 mg/dl while the reduction in BGL by aqueous extract at same dose from 269.46 to 114.38 mg/dl was observed. The ethanolic and aqueous extract reveals the reduction in the blood glucose level, this may be due to the presence of flavonoids constituents. The present study supports the traditional use of this plant in the treatment of diabetes and contributes as evidence for their use in traditional medicine.
- Subjects
ALLOXAN; BLOOD sugar; ANTILIPEMIC agents; RATS; HYPOGLYCEMIC agents; HYPERGLYCEMIA; PEOPLE with diabetes; HEALERS
- Publication
International Journal of Pharmacy & Life Sciences, 2020, Vol 11, Issue 7, p44
- ISSN
0976-7126
- Publication type
Article