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- Title
Cerebrospinal fluid biomarkers for Alzheimer's and vascular disease vary by age, gender, and APOE genotype in cognitively normal adults.
- Authors
Ge Li; Shofer, Jane B.; Petrie, Eric C.; Chang-En Yu; Wilkinson, Charles W.; Figlewicz, Dianne P.; Shutes-David, Andrew; Jing Zhang; Montine, Thomas J.; Raskind, Murray A.; Quinn, Joseph F.; Galasko, Douglas R.; Peskind, Elaine R.
- Abstract
Background: This study sought to evaluate gender and APOE genotype-related differences in the concentrations of cerebrospinal fluid (CSF) biomarkers for Alzheimer's disease (AD) and cerebrovascular injury across the life span of cognitively normal adults. Methods: CSF amyloid beta1-42 (Aβ42), phospho-tau-181 (p-tau181), and total tau were measured in 331 participants who were between the ages of 21 and 100. CSF E-selectin and vascular cell adhesion protein 1 (VCAM1) were measured in 249 participants who were between the ages of 50 and 100. Results: CSF total tau and p-tau181 increased with age over the adult life span (p < 0.01) with no gender differences in those increases. CSF Aβ42 concentration varied according to age, gender, and APOE genotype (interaction of age × gender × ε4, p = 0.047). CSF VCAM1, but not E-selectin, increased with age (p < 0.01), but both were elevated in men compared to women (p < 0.01). Conclusions: Female APOE-ε4 carriers appear at higher risk for AD after age 50. In contrast, men may experience a relatively higher rate of cerebrovascular injury in middle and early old age.
- Subjects
CEREBROSPINAL fluid; ALZHEIMER'S disease; VASCULAR diseases; AGE factors in Alzheimer's disease; VASCULAR cell adhesion molecule-1; BIOINDICATORS
- Publication
Alzheimer's Research & Therapy, 2017, Vol 9, p1
- ISSN
1758-9193
- Publication type
Article
- DOI
10.1186/s13195-017-0271-9