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- Title
Large-scale proteomics identifies MMP-7 as a sentinel of epithelial injury and of biliary atresia.
- Authors
Lertudomphonwanit, Chatmanee; Mourya, Reena; Lin Fei; Yue Zhang; Gutta, Sridevi; Li Yang; Bove, Kevin E.; Shivakumar, Pranavkumar; Bezerra, Jorge A.
- Abstract
The article discusses the study that identifies matrix metalloproteinase-7 (MMP-7) through the use of large scale proteomics of serum which is a biomarker of biliary atresia and a sentinel of epithelial injury. Topics mentioned include the high diagnostic performance when combined with γ glutamyltranspeptidase (GGT), the findings that MMP-7 is expressed by cholangiocytes, and the role as a therapeutic target.
- Subjects
MATRILYSIN; PROTEOMICS; PROTEIN expression; BILIARY atresia; EPITHELIUM; EPITHELIAL cells; GENETICS; WOUNDS &; injuries
- Publication
Science Translational Medicine, 2017, Vol 9, Issue 417, p1
- ISSN
1946-6234
- Publication type
Article
- DOI
10.1126/scitranslmed.aan8462