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- Title
Neoadjuvant chemotherapy induces breast cancer metastasis through a TMEM-mediated mechanism.
- Authors
Karagiannis, George S.; Pastoriza, Jessica M.; Yarong Wang; Harney, Allison S.; Entenberg, David; Pignatelli, Jeanine; Sharma, Ved P.; Xue, Emily A.; Cheng, Esther; D'Alfonso, Timothy M.; Jones, Joan G.; Anampa, Jesus; Rohan, Thomas E.; Sparano, Joseph A.; Condeelis, John S.; Oktay, Maja H.
- Abstract
The article discusses the findings of a study which examines the effectiveness of a neoadjuvant chemotherapy as treatment for breast cancer metastasis through a tumor microenvironment of metastasis (TMEM). The study highlights the use of a fixed tissue and intravital imaging of breast cancer patients tumors. It also notes the development of TMEM inhibitor function in improving the benefits of chemotherapy to breast cancer patients.
- Subjects
METASTATIC breast cancer; BREAST cancer patients; CANCER treatment; CANCER invasiveness; BREAST cancer treatment; ANTINEOPLASTIC agents; TUMOR microenvironment
- Publication
Science Translational Medicine, 2017, p1
- ISSN
1946-6234
- Publication type
Article
- DOI
10.1126/scitranslmed.aan0026