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- Title
Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer’s disease.
- Authors
Vijaya Kumar, Deepak Kumar; Se Hoon Choi; Washicosky, Kevin J.; Eimer, William A.; Tucker, Stephanie; Ghofrani, Jessica; Lefkowitz, Aaron; McColl, Gawain; Goldstein, Lee E.; Tanzi, Rudolph E.; Moir, Robert D.
- Abstract
The article discusses the use of amyloid beta-protein to protect against fungal and bacterial infections in cell culture models of Alzheimer's disease (AD). It examines the protective role of antimicrobial peptides in the defense against pathogens. It also cites the survival behavior of the host cellsafter infection with Candida albicans.
- Subjects
AMYLOID beta-protein; BACTERIAL diseases; CELL culture; ALZHEIMER'S disease diagnosis; PEPTIDE antibiotics
- Publication
Science Translational Medicine, 2016, Vol 8, Issue 340, p1
- ISSN
1946-6234
- Publication type
Article
- DOI
10.1126/scitranslmed.aaf1059