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- Title
Are There Enhanced MBP Autoantibodies in Autism?
- Authors
Libbey, Jane E.; Coon, Hilary H.; Kirkman, Nikki J.; Sweeten, Thayne L.; Miller, Judith N.; Stevenson, Edward K.; Lainhart, Janet E.; McMahon, William M.; Fujinami, Robert S.
- Abstract
Autoantibodies to central nervous system antigens, such as myelin basic protein (MBP), may play a role in autism. We measured autoantibody titers to MBP in children with autism, both classic onset and regressive onset forms, controls (healthy age- and gender-matched) and individuals with Tourette syndrome via enzyme-linked immunosorbent assays. We found a significant difference in autoantibody titers to MBP, not accounted for by age or medication, between Tourette and classic autism (both significantly lower) when compared to regressive autism, but not when compared to controls. Autoantibody responses against MBP are unlikely to play a pathogenic role in autism.
- Subjects
MEDICAL research; AUTISM in children; ASPERGER'S syndrome in children; MYELIN basic protein; BASIC proteins; ANTIGENS; MENTAL illness; DEVELOPMENTAL disabilities; PATHOLOGICAL psychology
- Publication
Journal of Autism & Developmental Disorders, 2008, Vol 38, Issue 2, p324
- ISSN
0162-3257
- Publication type
Article
- DOI
10.1007/s10803-007-0400-6