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- Title
Ca. Endozoicomonas cretensis: A Novel Fish Pathogen Characterized by Genome Plasticity.
- Authors
Weihong Qi; Cascarano, Maria Chiara; Schlapbach, Ralph; Katharios, Pantelis; Vaughan, Lloyd; Seth-Smith, Helena M. B.
- Abstract
Endozoicomonas bacteria are generally beneficial symbionts of diverse marine invertebrates including reef-building corals, sponges, sea squirts, sea slugs, molluscs, and Bryozoans. In contrast, the recently reported Ca. Endozoicomonas cretensiswas identified as a vertebrate pathogen, causing epitheliocystis in fish larvae resulting inmassivemortality. Here, we described the Ca. E. cretensis draft genome, currently undergoing genome decay as evidenced by massive insertion sequence (IS element) expansion and pseudogene formation. Many of the insertion sequences are also predicted to carry outward-directed promoters, implying that they may be able to modulate the expression of neighbouring coding sequences (CDSs). Comparative genomic analysis has revealed many Ca. E. cretensis-specific CDSs, phage integration and novel gene families. Potential virulence related CDSs and machineries were identified in the genome, including secretion systems and related effector proteins, and systems related to biofilmformation and directed cellmovement. Mucin degradation would be of importance to a fish pathogen, and many candidate CDSs associated with this pathway have been identified. The genome may reflect a bacteriumin the process of changing niche fromsymbiont to pathogen, through expansion of virulence genes and some loss of metabolic capacity.
- Subjects
FISH pathogens; GENOMES; BACTERIA; SYMBIOSIS; MARINE invertebrates; SPONGES (Invertebrates)
- Publication
Genome Biology & Evolution, 2018, Vol 10, Issue 6, p1363
- ISSN
1759-6653
- Publication type
Article
- DOI
10.1093/gbe/evy092