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- Title
Prognostic Role of Serum Lactate Dehydrogenase Beyond Initial Diagnosis: A Retrospective Analysis of Patients with Diffuse Large B Cell Lymphoma.
- Authors
Hong, Junshik; Yoon, Hyun-Hwa; ahn, Hee Kyung; Sym, Sun Jin; Park, Jinny; Park, Pil-Whan; ahn, Jeong Yeal; Park, Sanghui; Cho, Eun Kyung; Shin, Dong Bok; Lee, Jae Hoon
- Abstract
Background/Aims: Baseline serum lactate dehydrogenase (LDH) level is a well-known prognostic factor in patients with non-Hodgkin's lymphoma; however, its role beyond initial diagnosis has not yet been defined. Methods: This study was conducted as a retrospective analysis of patients with diffuse large B cell lymphoma (DLBCL) treated with R-CHOP21, who had undergone regular checks for LDH during immunochemotherapy (n = 119) and during the posttreatment follow-up period after complete remission (CR; n = 100). The 119 patients were classified into 4 groups according to their baseline and change in LDH level during treatment, and an analysis of tumor response and survival was performed. The value of LDH as a predictor for relapse was evaluated among the patients with regular follow-up visits after achieving CR. Results: An increased LDH level during immunochemotherapy had no impact on tumor response or survival, and only the LDH status 'before' treatment was a prognostic marker. The sensitivity, specificity, positive predictive value and negative predictive value of serum LDH for detecting relapse after CR were 47.4, 86.5, 9.3 and 98.3%, respectively. Conclusion: The measurement of LDH level beyond initial diagnosis has no clear benefit in predicting disease progression or relapse in patients with DLBCL treated with R-CHOP21. Copyright © 2013 S. Karger AG, Basel
- Subjects
BLOOD serum analysis; LACTATE dehydrogenase; DRUG therapy; LYMPHOMA treatment; FOLLOW-up studies (Medicine); BIOMARKERS
- Publication
Acta Haematologica, 2013, Vol 130, Issue 4, p305
- ISSN
0001-5792
- Publication type
Article
- DOI
10.1159/000353127